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Stosur was born in Brisbane, Queensland, the daughter of Tony and Diane, and has two brothers called Dominic and Daniel
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When she was six the family house and business on the Gold Coast was destroyed by a flood, and the family decided to move to Adelaide.[2]
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For christmas she got her first tennis racket
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Stosur attended Helensvale State High School on the Northern Gold Coast
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She went away on her first overseas trip at the age of 13, competing in the World Youth Cup in Jakarta, Indonesia.
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Stosur first played professional tennis in 1999 on the ITF circuit.
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At 14 she joined the Queensland Academy of Sport (QAS) under Geoff Masters
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In 2003 Stosur won her first WTA singles matches, reaching the third round of the Australian Open. She lost in the third round to No. 7 seed, Daniela Hantuchová. She also qualified for a WTA event in Memphis.
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In 2005 Stosur reached her first WTA tour final at her home event in Gold Coast, losing to Patty Schnyder.
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In 2006 Stosur represented Australia alongside Todd Reid at the Hopman Cup winning all of her singles matches.
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Stosur and Lisa Raymond successfully defended their doubles titles in Tokyo, Indian Wells and Miami.
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At the Beijing Olympics, Stosur was defeated in the second round of the singles tournament by no. 4 seed Serena Williams. In the doubles, Stosur (formerly ranked no. 1)
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At the Medibank International, she was defeated by No. 1 seed Serena Williams 6–3, 6–7(4), 7–5 before previously having 3 match points to take the match.
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After her success in 2009, Stosur decided to focus on singles and take part in doubles less.